He frequently collaborates as a guest conductor with the S. Moniuszko Poznań Opera House and the A. Rubinstein Philharmonic in Łódź. At the Opera of Poznań he performed following premieres: Stravinsky Le sacre du printemps (2013), and Le rossignol (2014), Ravel L’enfant et les sortileges (2014), Tchaikovski Balanchine’s Serenade (2015) and world premieres: Coli The Angel of the Odd (2014), Wojciechowski Ofelia (2018), Przybylski Anhelli (2019), Zapała Solastalgia (2021). Other significant stage premieres conducted by Grzegorz Wierus were: Nepelski Solaris electronic opera (2008, Malta Festival, Poznań), Haendel Giulio Cesare in Egitto (2009, Kraków-Nowy Sącz), Zagajewski Nature morte (2011-12), Weill Die sieben Todsünden (2015, Warsaw Chamber Opera), Oratorium Dance Project (2011, Chorea Theater, Łódź), Halka/Haiti project (2015, Zachęta – National Gallery of Art, Haiti-Venice), Wszyscy jesteśmy Bogami (2018, Polish Dance Theater, Poznań).
He collaborated also with: Cracow Philharmonic, Warsaw Chamber Opera, Polish Chamber Philharmonic in Sopot, Szeged Symphony Orchestra, Stara Zagora State Opera, Moravian Philharmonic in Olomouc, Beethoven Academy Orchestra (Cracow), Sudeten Philharmonic in Wałbrzych, Ensemble Nostri Temporis (Kiev, Ukraine).
He is particularly passionate about activities aimed at popularizing musical culture including family concerts, music workshops and educational events.